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Treatment of Malignant GliomaA Controlled Study of Chemotherapy and Irradiation
William R. Shapiro, MD;
Dean F. Young, MD
Arch Neurol. 1976;33(7):494-500.
Abstract
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• Thirty-three patients with malignant glioma were randomly divided into two groups after extensive tumor resection. Those in group A received, every five to eight weeks, a course of chemotherapy consisting of intravenously administered carmustine, 80 mg/sq m /day for three days, and vincristine sulfate, 1.4 mg/sq m on days 1 and 8. Patients in group B were treated identically and received radiation therapy (RT) as well, 4,500 rads whole brain plus 1,500 rads to the side of the tumor. The median survival time of group A was 30 weeks, while that of group B was 44.5 weeks, but the overall survival curves were not significantly different. The median survival times exceeded the 17 weeks reported elsewhere in comparable patients not receiving postoperative therapy. Estimates of the quality of survival suggested (1) the two groups were not comparable following randomization, possibly influencing the results; and (2) postoperative radiation and chemotherapy do not increase morbidity and offer a longer period than other treatments during which patients' conditions remain stable or improve.
Author Affiliations
From the departments of neurology, Memorial Sloan-Kettering Cancer Center, New York, and Cornell University Medical College, New York. Dr Young is now with the Department of Neurosciences, New Jersey Medical School, Newark.
Footnotes
Accepted for publication Oct 27, 1975.
Reprint requests to Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021 (Dr Shapiro).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Chou et al.
Arch Neurol 1979;36:739-749.
ABSTRACT
Glioblastoma Multiforme-Reply
Shapiro
Arch Neurol 1977;34:131-132.
ABSTRACT
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