This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal

Review and Report of Five Cases

Thomas R. Browne, MD; Raymond D. Adams, MD; Glenn H. Roberson, MD

Arch Neurol. 1976;33(6):435-441.

Abstract
• Eighty-five cases of hemangioblastoma of the spinal cord are reviewed, including five new ones. While current views of the incidence, histology, and cytogenesis are presented, the main purpose of this article is to call attention to the identifying clinical and radiological characteristics of these spinal tumors. Median age at onset of symptoms was 30 years. The ratio of men to women was 1.1:1. Presenting symptoms were usually radicular pain or posterior column sensory loss or both. The lesions were most often single (79%), intramedullary (60%), and located in the cervical or thoracic spinal cord. There was associated syringomyelia in 67% of intramedullary cases and meningeal varicosities in 48% of all cases. Lindau disease and hemangioblastomas in other central nervous system locations were present in 33% of cases. The characteristic roentgenographic picture is a densely vascular tumor in association with a larger avascular syrinx and meningeal varicosities. Surgery is the only definitive treatment.

Author Affiliations
From the Charles S. Kubik Laboratory for Neuropathology (Drs Browne and Adams), James Homer Wright Pathology Laboratory, Massachusetts General Hospital, and the departments of neurology-neuropathology (Drs Browne and Adams), pathology (Drs Browne and Adams), and neuroradiology (Dr Roberson), Harvard Medical School, Boston.

Footnotes
Accepted for publication June 28, 1975.

Reprint requests to Department of Neurology, Massachusetts General Hospital, Boston, MA 02114 (Dr Browne).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Neurologic Manifestations of von Hippel-Lindau Disease
Butman et al.
JAMA 2008;300:1334-1342.
ABSTRACT | FULL TEXT  

MR Findings in Spinal Hemangioblastoma: Correlation with Symptoms and with Angiographic and Surgical Findings
Chu et al.
Am. J. Neuroradiol. 2001;22:206-217.
ABSTRACT | FULL TEXT  

Neoplasms of the Spinal Cord and Filum Terminale: Radiologic-Pathologic Correlation
Koeller et al.
RadioGraphics 2000;20:1721-1749.
ABSTRACT | FULL TEXT  

MR Imaging of Spinal Hemangioblastoma
Baker et al.
Am. J. Roentgenol. 2000;174:377-382.
FULL TEXT  

Radionuclide Angiography of Vascular Lesions of the Spinal Cord: Its Efficacy in Selecting Patients for Spinal Angiography
Obayashi et al.
Arch Neurol 1980;37:572-574.
ABSTRACT  

Spinal Cord Arteriovenous Malformations
Slade
VASC ENDOVASCULAR SURG 1979;13:87-94.
ABSTRACT