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Prophylactic Effects of Phenytoin, Phenobarbital, and Carbamazepine Examined in Kindling Cat Preparations
Juhn A. Wada, MD, FRCP(C);
Mitsumoto Sato, MD;
Akira Wake, MD;
John R. Green, MD, PhD;
Allan S. Troupin, MD
Arch Neurol. 1976;33(6):426-434.
Abstract
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• Prophylactic effects of phenobarbital, phenytoin (diphenylhydantoin), and carbamazepine were examined in amygdaloid kindling preparations in cats. Daily electrical stimulation was delivered at the time of peak plasma levels. Comparative examination of the chronological pattern of the clinical seizure development, after discharge growth, and formation of distant independent spike foci was made between periods of kindling with chronic drug administration and of rekindling without drugs. Both phenobarbital and carbamazepine were effective, but phenytoin was totally ineffective. Prophylactic action of phenobarbital and carbamazepine was mainly through the suppression of the development of motor seizure manifestations in the former and the same with the development of sustained after discharge in the latter. The kindling preparation appears to possess many desirable features as an ideal model of human epilepsy for the purpose of assessment and recruitment of potential antiepileptic drugs and development of a rational pharmacotherapeutic approach for the management and prevention of seizure disorder.
Author Affiliations
From the Division of Neurological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada (Drs Wada, Wake, and Sato), and the Seizure Clinic, University of Washington, Seattle (Drs Green and Troupin).
Footnotes
Accepted for publication June 13, 1975.
Deceased.
Read before the American Epilepsy Society, New York, Dec 6, 1973.
Reprint requests to Health Sciences Centre Hospital, University of British Columbia, Vancouver, British Columbia V6T 1W5, Canada (Dr Wada).
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Arch Neurol 1977;34:389-395.
ABSTRACT
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