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Histocompatibility Typing in Amyotrophic Lateral Sclerosis
Jack P. Antel, MD, FRCP(C);
Barry G. W. Arnason, MD;
Thomas C. Fuller, PhD;
James R. Lehrich, MD
Arch Neurol. 1976;33(6):423-425.
Abstract
• Histocompatibility (HL-A) phenotypes of 44 unrelated white patients from the greater Boston area with amyotrophic lateral sclerosis (ALS) and 200 white controls were compared. In the overall ALS group, an increased frequency of HL-A3 was noted (43% vs 25%, P <.05). Thirty-eight patients had rapidly progressive disease; among this group the HL-A3 incidence was 50% (P <.005). Six patients had slowly progressive disease, none had HL-A3, and five had HL-A12. The HL-A antigens may link with disease severity in ALS.
Author Affiliations
From the Department of Neurology (Drs Antel, Arnason, and Lehrich) and the Massachusetts General Hospital Transplantation Unit, Department of Surgery (Dr Fuller), Harvard Medical School, Boston. Dr Arnason is now with the Department of Neurology, University of Chicago, Pritzker School of Medicine.
Footnotes
Accepted for publication Dec 18, 1975.
Reprint requests to Department of Neurology, University of Chicago, Pritzker School of Medicine, 950 E 59th St, Chicago, IL 60637 (Dr Arnason).
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