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Antibodies to Vaccinia and Measles Viruses in Multiple Sclerosis Patients
Hiroyuki Miyamoto, MD, PhD;
Jonathan E. Walker, MD;
Arthur H. Ginsberg, MD;
Jack S. Burks, MD;
Kenneth McIntosh, MD;
C. Henry Kempe, MD
Arch Neurol. 1976;33(6):414-417.
Abstract
• A virologic comparison was made of 144 patients with multiple sclerosis, 34 of their healthy siblings, and 40 patients with other neurologic diseases (OND). Antibodies in serum and cerebrospinal fluid (CSF) to vaccinia and measles viruses were measured, and these were correlated in the multiple sclerosis patients with the clinical characteristics of their disease. The CSF antibody to vaccinia virus was more frequent and at a higher titer in multiple sclerosis patients than in either control group. Moreover, a statistically significant increase was found in both frequency and titer of CSF vaccinia antibody in patients with the progressive form of the disease as compared with those classified as relapsing-remitting. Statistically significant differences between multiple sclerosis patients and their siblings were not observed for CSF or serum measles virus antibody, although both groups had significantly higher serum antibody titers than patients with OND.
Author Affiliations
From the Research Institute for Microbial Disease, Osaka University, Japan (Dr Miyamoto), departments of neurology, Veterans Administration Hospital (Drs Walker, Ginsberg, Burks) and Colorado General Hospital (Drs Ginsberg and Burks), departments of pediatrics (Drs McIntosh and Kempe) and microbiology (Dr Kempe), University of Colorado Medical Center, Denver.
Footnotes
Accepted for publication May 15, 1975.
Reprint requests to 4200 E Ninth Ave, Denver, CO 80220 (Dr Kempe).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Comprehensive Viral Immunology of Multiple Sclerosis: II. Analysis of Serum and CSF Antibodies by Standard Serologic Methods
Cremer et al.
Arch Neurol 1980;37:610-615.
ABSTRACT
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