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James R. Lehrich, MD; Barry G. W. Arnason, MD

Arch Neurol. 1976;33(6):404-405.

Abstract
• Serum neutralizing (Nt) antibodies to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and histocompatibility (HL-A) types, were determined in multiple sclerosis (MS) patients and in control subjects. Titers of Nt antibodies to HSV-1 and to HSV-2 were increased among subjects bearing HL-A3 or HL-A7 or both, whether they suffered from MS or not. The increases were statistically significant in the MS group. The MS and control groups did not differ significantly in levels of HSV-1 or HSV-2 Nt antibodies.

Author Affiliations
From the Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston.

Footnotes
Accepted for publication Dec 18, 1975.

Reprint requests to Department of Neurology, Massachusetts General Hospital, Boston, MA 02114 (Dr Lehrich).

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