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Johan A. Aarli, MD

Arch Neurol. 1976;33(4):296-299.

Abstract
• Serum concentrations of IgA, IgG, and IgM were determined by immunodiffusion technique in 184 epileptic patients and 95 healthy individuals. Twenty-one percent of adult and 42% of children patients receiving anticonvulsants had serum IgA levels below 0.6 mg/ml (the lowest value detected in normal sera). Serum concentrations in non-drug-taking epileptic patients were normal. Deviations in IgG/IgM concentrations were smaller and less consistent.

Serum IgA level was determined at intervals before and during phenytoin treatment. A fall in the IgA level occurred in several patients. In two patients, IgA deficiency developed within two to three months of treatment. Low IgA-responders were more frequent among men and children. The IgA anomaly was not specific for any type of epilepsy.

Author Affiliations
From the Department of Neurology, School of Medicine, University of Bergen, Bergen, Norway.

Footnotes
Accepted for publication Sept 24, 1975.

Reprint requests to Department of Neurology, 5016 Haukeland sykehus, Bergen, Norway (Dr Aarli).

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