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I. Glutamic Dehydrogenase

Michael D. Norenberg, MD

Arch Neurol. 1976;33(4):265-269.

Abstract
• Results of a histochemical study of glutamic dehydrogenase in experimental portal-systemic encephalopathy with hyperammonemia indicate that the enzyme's activity in brain was increased in all stages of the encephalopathy, and this increase appeared to be localized exclusively in astrocytes. The results are consistent with the view that the astrocyte has a critical role in ammonia metabolism in brain, probably in ammonia detoxification. The findings, moreover, indicate that one pool of glutamate, possibly the small pool, is located in the astrocyte.

Author Affiliations
From the research and laboratory services, Verterans Administration Hospital, and the Department of Pathology, University of Colorado Medical Center, Denver.

Footnotes
Accepted for publication April 7, 1975.

Read in part before the 50th annual meeting of the American Association of Neuropathologists, Boston, June 7, 1974.

Reprint requests to Laboratory Service, Veterans Administration Hospital, 1055 Clermont St, Denver, CO 80220 (Dr Norenberg).

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Science 1977;195:1356-1358.
ABSTRACT