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I. Functional Aspects of Visual Cortex

D. Denny-Brown, MD; Richard A. Chambers, MD

Arch Neurol. 1976;33(4):219-227.

Abstract
• The first part of the Bennett Lecture for 1975 is a description of the dissociation of visual perception in the macaque monkey by ablation of area 17 on the one hand, and of areas 18 and 19 on the other. Bilateral removal of area 17, with careful preservation of a great part of areas 18 and 19, and of the inferior pulvinar, resulted in loss of binocular fixation, loss of visual recognition of still objects, and loss of visuosocial behavior such as grimacing and vocalization. There remained excellent visuospatial orientation and reaching for moving peripheral visual targets. Removal of areas 18 and 19, with isolation of area 17 from the remainder of cortex, was accomplished in two animals and left intact the ability to distinguish and sort out still objects by vision, with intact fixation, and visuosocial behavior. Spatial orientation was then easily confused by movement.

Footnotes
Accepted for publication Dec 11, 1975.

Read by Dr Denny-Brown at the sixth annual Foster Elting Bennett Lecture before the annual meeting of the American Neurological Association, New York, June 4, 1975. The lecture was derived from two projects in collaboration with others, as well as a number of personal observations. It is accordingly presented here in two parts: part 1 relates to experiments at the Harvard Neurological Unit of Boston City Hospital (1951-1953), with the assistance of Dr Chambers (Research Fellow in Neurology in 1953 and 1956); part 2 relates in part to work by Dr Denny-Brown on the colliculus at Boston City Hospital (1961-1963) and in part to work on the tegmentum carried out at the New England Regional Primate Center (1968-1970), with the assistance of Edwin G. Fischer, MD (Research Fellow in Neurosurgery, 1968-1969). Dr Chambers now heads the Department of Neurology, Jefferson Medical College, Philadelphia.

Reprint requests to New England Regional Primate Research Center, Southborough, MA 01772 (Dr Denny-Brown).

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