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Findings in Human and Animal Muscular Dystrophies

H. Bruce Bosmann, PhD; Douglas M. Gersten, PhD; Robert C. Griggs, MD; John L. Howland, PhD; Michael S. Hudecki, PhD; Surendra Katyare, PhD; Jack McLaughlin, PhD

Arch Neurol. 1976;33(2):135-138.

Abstract
• Electrophoretic mobility measurements were made of red blood cells obtained from patients with Duchenne and myotonic muscular dystrophy, from dystrophic mice and chickens, and from corresponding controls. Alterations in the erythrocyte surface electrokinetic properties were found in dystrophic mice and chickens and in many, but not all, patients with muscular dystrophy. The results are consistent with the concept of muscular dystrophy as a systemic membrane disease not limited to muscle.

Author Affiliations
From the Department of Pharmacology and Toxicology (Drs Bosmann, Gersten, and McLaughlin) and the Departments of Neurology, Pediatrics and Medicine (Dr Griggs), University of Rochester School of Medicine and Dentistry, Rochester, NY; the Committee on Biochemistry, Bowdoin College, Brunswick, Me (Drs Howland and Katyare); and the Department of Biochemistry, State University of New York at Buffalo (Dr Hudecki).

Footnotes
Accepted for publication Jan 3, 1975.

Reprint requests to 260 Crittenden Blvd, Rochester, NY 14642 (Dr Bosmann).

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ABSTRACT