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Effects of Occlusion of One Middle Cerebral Artery on Single-Unit Activity in Cats

Wolf-Dieter Heiss, MD; Toru Hayakawa, MD; Arthur G. Waltz, MD

Arch Neurol. 1976;33(12):813-820.

Abstract
• To assess the effects of ischemia on neuronal function, the action potentials of 261 individual cortical neurons were recorded extracellularly and related to regional cerebral blood flow (CBF) measured by hydrogen clearance in 19 cats, seven of which had the left middle cerebral artery occluded during a recording. The onset of ischemia could be associated with transient increases of activity, including "seizure discharges," as well as cessation of activity. No activity was noted at CBF less than 0.18 ml/gm/min; at higher (but ischemic) values for CBF, abnormal patterns of activity frequently were recorded. One neuron recovered function after cessation in association with an increase of CBF, indicating a potential for the restoration of function of ischemic neurons by effective therapeutic measures.

Author Affiliations
From the Cerebrovascular Clinical Research Center, Department of Neurology, University of Minnesota, Minneapolis. Dr Heiss is now with the Department of Neurology, University of Vienna. Dr Hayakawa is now with the Department of; Neurosurgery, Osaka (Japan) University. Dr Waltz is now with the Department of Neurology, Pacific Medical Center, San Francisco.

Footnotes
Accepted for publication May 19, 1976.

Reprint requests to Department of Neurology, Pacific Medical Center, PO Box 7999, San Francisco, CA 94120 (Dr Waltz).

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