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Jan-Edvin Olsson, MD; Erna Möller, MD; Hans Link, MD

Arch Neurol. 1976;33(12):808-812.

Abstract
• Eight families from southern Sweden having two or more members with multiple sclerosis (MS) were typed for various alleles of the HLA system. The MS patients within each family shared one major histocompatibility system (MHS) haplotype, which was identical to the hitherto-described MS-associated haplotype A3B7Dw2 only in two of the families. Healthy relatives of MS patients were often found to carry the same haplotype as the affected members, which makes an estimate of the degree of penetrance of disease in individuals carrying the MS-predisposing MHS-linked gene possible.

Author Affiliations
From the Department of Neurology, University Hospital, Lund (Dr Olsson) and Linkoping (Dr Link), and the Transplantation Immunology Laboratory, Huddinge Sjukhus, Huddinge (Dr Möller), Sweden.

Footnotes
Accepted for publication May 12, 1976.

Reprint requests to Department of Neurology, University Hospital, S-221 85, Lund, Sweden (Dr Olsson).