This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (176)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Henry J. M. Barnett, MD, FRCP(C); Michael W. Jones, MD, FRCP(C); Derek R. Boughner, MD, FRCP(C); William J. Kostuk, MD, FRCP(C)

Arch Neurol. 1976;33(11):777-782.

Abstract
• Twelve patients who had no evidence of arteriosclerotic cerebral vascular disease, lacked hypertension or coagulation defect, and had not been receiving contraceptive therapy had recurrent transient cerebral ischemic attacks (TIAs) and partial nonprogressive strokes. All had prolapsing mitral valve proved by angiocardiography. The average age was 38 years, compared with 62 years in a larger series of patients with TIA associated with arteriosclerosis. We propose that the ischemic events are related to emboli emanating from the abnormal mitral valve with or without an associated paroxysmal cardiac arrhythmia.

Author Affiliations
From the Departments of Clinical Neurological Sciences (Drs Barnett and Jones) and Medicine (Drs Boughner and Kostuk), University Hospital, London, Ontario.

Footnotes
Accepted for publication April 26, 1976.

Read in part before the annual meeting of the American Neurological Association, New York, June 2, 1975.

Reprint requests to Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada, N6A 5A5 (Dr Barnett).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
2006 WRITING COMMITTEE MEMBERS et al.
Circulation 2008;118:e523-e661.
FULL TEXT  

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Bonow et al.
J Am Coll Cardiol 2008;52:e1-e142.
FULL TEXT  

Valvular and Structural Heart Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Salem et al.
Chest 2008;133:593S-629S.
ABSTRACT | FULL TEXT  

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons
Bonow et al.
J Am Coll Cardiol 2006;48:e1-e148.
FULL TEXT  

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co-Sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline.
Sacco et al.
Circulation 2006;113:e409-e449.
ABSTRACT | FULL TEXT  

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co-Sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline.
Sacco et al.
Stroke 2006;37:577-617.
ABSTRACT | FULL TEXT  

Antithrombotic Therapy in Valvular Heart Disease--Native and Prosthetic: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
Salem et al.
Chest 2004;126:457S-482S.
ABSTRACT | FULL TEXT  

Cerebral Ischemic Events After Diagnosis of Mitral Valve Prolapse: A Community-Based Study of Incidence and Predictive Factors
Avierinos et al.
Stroke 2003;34:1339-1344.
ABSTRACT | FULL TEXT  

Antithrombotic Therapy in Valvular Heart Disease
Salem et al.
Chest 2001;119 :207S-219S.
FULL TEXT  

Atherosclerosis of the ascending aorta is an independent predictor of long-term neurologic events and mortality
Davila-Roman et al.
J Am Coll Cardiol 1999;33:1308-1316.
ABSTRACT | FULL TEXT  

35th Annual Meeting -- American College of Angiology Orlando, Florida -- October, 1988 Symposium Proceedings: Neurologic Aspects of Mitral Valve Prolapse
Heck
ANGIOLOGY 1989;40:743-751.
ABSTRACT  

Unilateral Moya Moya Disease in an Adult A Case History
Gomez and Hogan
ANGIOLOGY 1987;38:342-346.
ABSTRACT  

Exercise-Related Middle Cerebral Artery Territory Stroke
DeCarli et al.
Arch Neurol 1987;44:11-12.
ABSTRACT  

Nonhemorrhagic Cerebral Infarction in Young Adults
Adams et al.
Arch Neurol 1986;43:793-796.
ABSTRACT  

Nonseptic Cerebral Emboli of Cardiac Origin
Martin and Biller
Arch Intern Med 1984;144:1997-1999.
ABSTRACT  

Mitral Valve Prolapse: Association With Bizarre Behavior, a Confusional State, and Aphasia
Schatz and Chandraratna
Arch Intern Med 1982;142:1215-1216.
ABSTRACT  

Vascular Manifestations in Patients With Ehlers-Danlos Syndrome
Hunter et al.
Arch Surg 1982;117:495-498.
ABSTRACT  

The Click-Murmur Syndrome: A Clinical Problem in Diagnosis and Treatment
Cheitlin and Byrd
JAMA 1981;245:1357-1361.
ABSTRACT  

Therapy of Ischemic Cerebrovascular Disease
BYER and EASTON
ANN INTERN MED 1980;93:742-756.
ABSTRACT  

The Spectrum of Cardiac Defects in the Ehlers-Danlos Syndrome, Types I and III
LEIER et al.
ANN INTERN MED 1980;92:171-178.
ABSTRACT  

Transient Ischemic Attack Associated With Mitral Systolic Clicks
Saffro and Talano
Arch Intern Med 1979;139:693-694.
ABSTRACT  

Transmural Myocardial Infarction: With the Prolapsing Mitral-Leaflet Syndrome and Normal Coronary Arteries
Imaizumi et al.
Arch Intern Med 1978;138:1354-1355.
ABSTRACT  

Palpitations and Late Systolic Murmur in a Young Man
Jacobs et al.
Arch Intern Med 1977;137:911-913.
ABSTRACT