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Pathogenesis of Chronic Degenerative Changes in the CNS

Izabella Zgorniak-Nowosielska, MD; Yuzo Iwasaki, MD; Thomas Tachovsky, PhD; Ryuichi Tanaka, MD; Hilary Koprowski, MD

Arch Neurol. 1976;33(1):55-62.

Abstract
• The pathogenicity of the 6/94 strain of parainfluenza type 1 virus, originally isolated from multiple sclerosis brain, was studied in adult mouse brains. Intracerebral inoculation of the virus caused mononuclear cell infiltration in the form of perivascular cuffing and a diffuse exudation into the parenchymal tissue, preferentially in cerebral white matter, that resulted in marked degeneration over a 90-day observation period. Immunofluorescent staining revealed viral antigen in the ependymal lining cells only during the first seven days after infection. No correlation was found between the severity of the brain lesions and the level of circulating antiviral antibody, preexisting or newly produced.

Author Affiliations
From the Multiple Sclerosis Research Center of The Wistar Institute; and the Department of Neurology, University of Pennsylvania, Philadelphia.

Dr. Zgorniak-Nowosielska is a fellow of the Wistar Institute from the Academy of Medicine, Krakow, Poland.

Footnotes
Accepted for publication Dec 26, 1974.

Reprint requests to the Wistar Institute, 36th Street at Spruce, Philadelphia, PA 19104 (Dr Koprowski).

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