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Electrophysiologic, Morphologic, and Biochemical Studies

David I. Graham, MB, ChB, PhD; Pacifico V. de Jesus, MD; David E. Pleasure, MD; Nicholas K. Gonatas, MD

Arch Neurol. 1976;33(1):40-48.

Abstract
• Adult rats given high orally administered doses of triethyltin (TET) sulfate lost weight, developed hind limb wasting, and became paraplegic or quadriplegic within three weeks of intoxication. A 33% reduction in the motor nerve conduction velocity (MNCV) of the sciatic nerve in the absence of significant demyelination was observed. There was observed, however, intramyelinic edema formation and an increased number of axonal neurofilaments and neurotubules; changes that paralleled the decrease in MNCV during the period of intoxication. Although the animals became asymptomatic and the MNCV normalized within two to three weeks of discontinuing the TET intoxication, the intramyelinic vacuoles and the increased numbers of neurofilaments and neurotubules persisted.

Author Affiliations
From the departments of pathology (division of neuropathology) (Drs Graham and Gonatas) and neurology (Drs de Jesus and Pleasure), University of Pennsylvania School of Medicine, Philadelphia. Dr Graham is now at Southern General Hospital, Glasgow, Scotland.

Footnotes
Accepted for publication Oct 14, 1974.

This paper was presented as an abstract at the third International Congress on Muscle Diseases, Newcastle-upon-Tyne, England, Sept 15, 1974.

Reprint requests to Veterans Administration Hospital, Neuromuscular Physiology Laboratory, West Spring Street, West Haven, CT 06516 (Dr de Jesus).

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