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Harry Openshaw, MD; Ivan Diamond, MD, PhD

Arch Neurol. 1975;32(9):640-641.

Abstract
• Statistically significant cerebral arteriovenous differences of D-β-hydroxybutyrate were found in rats made diabetic by administration of streptozotocin. The amount of D-β-hydroxybutyrate extracted by the brain in diabetic animals increased with increasing arterial concentrations and the extraction ratios were comparable to those found in animals and humans with ketosis due to other causes.

Author Affiliations
From the departments of neurology (Dr. Diamond) and pediatrics (Dr. Openshaw), University of California, School of Medicine, San Francisco.

Footnotes
Accepted for publication Sept 30, 1974.

Reprint requests to Department of Neurology, University of California, San Francisco, CA 94143 (Dr. Diamond).

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