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  Vol. 32 No. 9, September 1975 TABLE OF CONTENTS
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Cerebral Blood Flow in Dementia

Vladimir C. Hachinski, MD, FRCP(C); Linnette D. Iliff, M Phil, PhD; Elias Zilhka, M Sc; George H. Du Boulay, MB, MRCP, FFR; Victor L. McAllister, MB, DMRD, FFR; John Marshall, MD, FRCP (Edin), FRCP (Lond), DPM; Ralph W. Ross Russell, MA, MD, DM, FRCP; Lindsay Symon, FRCS (Edin), FRCS (Eng)

Arch Neurol. 1975;32(9):632-637.


Abstract

• Twenty-four patients of comparable age, blood pressure, and degree of dementia were classified by an "Ischemic Score" based on clinical features into "multi-infarct" and "primary degenerative" dementia. Regional cerebral blood flow (CBF) was measured by the intracarotid xenon 133 method. Both groups showed a decreased proportion of rapidly clearing brain tissue (largely gray matter). Cerebral blood flow per 100 gm brain per minute was normal in the primary degenerative group but low in the multi-infarct group. This suggests the blood flow is adequate for metabolic needs of the brain in patients with primary degenerative dementia but inadequate for those with multi-infarct dementia. There was no correlation between degree of dementia and CBF in the primary degenerative group but an inverse relationship existed in the multi-infarct group. Reactivity of blood vessels to reduction of arterial carbon dioxide pressure was normal in both groups.



Author Affiliations

From the Institute of Neurology and National Hospitals for Nervous Diseases, Queen Square, London. Dr. Hachinski is now at Sunnybrook Hospital, Toronto.


Footnotes

Accepted for publication Oct 28, 1974.

Reprint requests to Graham MacLachlan Stroke Unit, Sunnybrook Hospital, University of Toronto Clinic, 2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada (Dr. Hachinski).



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