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Electrophysiologic Alterations and Histopathologic Findings

Donald R. Crapper, MD, FRCP (C); Arthur J. Dalton, PhD; Macey Skopitz, P Eng; John W. Scott, MD; Vladimir C. Hachinski, MD, FRCP (C)

Arch Neurol. 1975;32(9):618-623.

Abstract
• Progressive electroencephalographic disorganization and decreased voltage amplitude in the late components of the averaged visual evoked potentials were recorded in the last two years of life of a patient with Down disease and Alzheimer degeneration. Taken together with quantitative histopathologic findings, the electrophysiologic alterations are interpreted in terms of recent evidence from an experimental animal model of dementia. Neurons with neurofibrillary degeneration become electrically inactive and contribute to the loss of voltage generators associated with neuron death in Alzheimer disease. Loss of voltage generators may result in disfacilitation and disinhibition of surviving neurons, thus causing the loss of normal rhythms.

Author Affiliations
From the departments of physiology and medicine, University of Toronto, Toronto (Drs. Crapper, Scott, and Hachinski, and Mr. Skopitz) and the Surrey Place Centre, Toronto (Dr. Dalton).

Footnotes
Accepted for publication Sept 17, 1974.

Reprint requests to Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada (M5S-1A8) (Dr. Crapper).

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