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Serotonin-Induced Muscle Weakness in Man?

Michael Swash, MD, MRCP; Kathleen P. Fox; Andrew R. Davidson, MB, MRCP

Arch Neurol. 1975;32(8):572-574.

Abstract
A myopathy, which improved with cyproheptadine hydrochloride therapy, developed in a patient with carcinoid syndrome of ten years' duration. Biopsy examination revealed advanced atrophy of type II muscle fibers, with type I fiber preponderance. Many of the small fibers had degenerated. Carcinoid myopathy may be due to excess circulating serotonin.

Author Affiliations
FILMT

From the Department of Neurology, Section of Neurological Sciences, the London Hospital.

Footnotes
Accepted for publication April 11, 1975.

Reprint requests to the Department of Neurology, the London Hospital, EL 1BB, United Kingdom (Dr. Swash).

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