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Eugene S. Flamm, MD; Jhino Kim, MD; Joseph Lin, MD; Joseph Ransohoff, MD

Arch Neurol. 1975;32(8):569-571.

Abstract
Experimental cerebral vasospasm was studied in cat and monkey models. In the cat, the basilar artery was exposed by a transclival approach and spasm induced by the application of blood to the vessel. In the monkey, spasm was produced by injecting blood into the subarachnoid space. Vessel size was determined in the cat by direct observation and, in the monkey, by cerebral angiography. Several agents known to alter the synthesis and degradation of cyclic adenosine monophosphate (AMP) were used to modify the vasospasm produced. Isoproterenol (Norisodrine) and aminophylline were effective in reversing cerebral vasospasm when applied topically and when administered parenterally. It is suggested that manipulation of the cyclic AMP pathways may be an effective method of controlling cerebral vasospasm.

Author Affiliations
From the departments of neurosurgery and radiology, New York University Medical Center.

Footnotes
Accepted for publication Sept 17, 1974.

Read in part at the Annual Meeting of the American Neurological Association, Boston, June 11, 1974.

Reprint requests to Milbank Research Laboratories, 340 E 24th St, New York, NY 10010 (Dr. Flamm).

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