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Guanidine and Neuromuscular TransmissionII. Effect on Transmitter Release in Response to Repetitive Nerve Stimulation
Marina A. Kamenskaya, PhD;
Dan Elmqvist, MD;
Stephen Thesleff, MD
Arch Neurol. 1975;32(8):510-518.
Abstract
The effect of guanidine on the neuromuscular transmission in human intercostal and mouse diaphragm muscle in vitro during repetitive nerve stimulation was studied. The drug greatly increased the release of acetylcholine (ACh) quanta by nerve impulses at low frequencies of nerve stimulation and at the beginning of tetani at high frequencies of stimulation. The effect was shown to be produced by an increase in fractional release from an unchanged store of ACh quanta available for immediate release. This seems to explain why guanidine has a poor therapeutic effect in myasthenia gravis but a good effect in the myasthenic syndrome.
Author Affiliations
From the departments of pharmacology and clinical neurophysiology, University of Lund, Sweden. Dr. Kamenskaya is now at Lomonosow State University, Moscow.
Footnotes
Accepted for publication Oct 17, 1974.
Reprint requests to Department of Clinical Neurophysiology, University Hospital, S-221 85 Lund 5, Sweden (Dr. Elmqvist).
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