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I. Effect on Transmitter Release Occurring Spontaneously and in Response to Single Nerve Stimuli

Marina A. Kamenskaya, PhD; Dan Elmqvist, MD; Stephen Thesleff, MD

Arch Neurol. 1975;32(8):505-509.

Abstract
The effect of guanidine on neuromuscular transmission was studied in human intercostal muscle and mouse diaphragm preparations in vitro. Guanidine greatly increased the number of acetylcholine (ACh) quanta released by a single motor nerve action potential. This effect of guanidine was greater at junctions with a low quantum content. The spontaneous release of ACh quanta was not substantially changed by guanidine. No change was found in the postsynaptic sensitivity to ACh released from the motor nerve or iontophoretically applied to the muscle fiber. Effects of the drug had slow onset and were very long-lasting and resistant to wash.

Author Affiliations
From the departments of pharmacology and clinical neurophysiology, University of Lund, Sweden. Dr. Kamenskaya is now at Lomonosow State University, Moscow.

Footnotes
Accepted for publication Oct 17, 1974.

Reprint requests to Department of Clinical Neurophysiology, University Hospital, S-221 85 Lund 5, Sweden (Dr. Elmqvist).

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Guanidine and Neuromuscular Transmission: II. Effect on Transmitter Release in Response to Repetitive Nerve Stimulation
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Arch Neurol 1975;32:510-518.
ABSTRACT