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Brief Hypoxia-Ischemia Initially Damages Cerebral Neurons
David E. Levy, MD;
James B. Brierley, MD;
David G. Silverman;
Fred Plum, MD
Arch Neurol. 1975;32(7):450-456.
Abstract
Rats were studied during cerebral hypoxic ischemia to determine whether neurons or blood vessels suffered the first damage. Ten or more minutes of unilateral carotid artery occlusion combined with systemic hypoxemia (PaO2, 21 mm Hg) produced neuronal but not vascular damage in the ipsilateral cerebral hemispheres of 18 of 29 rats (62%); two and five minute stresses caused no visible neuronal abnormalities. The longer exposures produced more widespread damage, and neuronal loss and gliomesodermal reaction were evident after prolonged survival. Early neuronal changes correlated with abnormalities of motor behavior (P <.005). Despite neuronal damage that was sometimes extensive, vascular no-reflow developed in only one of 24 animals after 20 and 30 minutes of hypoxia-ischemia. Production of neuronal and neurological abnormalities in the absence of hypotension or vascular no-reflow indicates that hypoxia-ischemia initially damaged cerebral neurons.
Author Affiliations
From the Department of Neurology, New York Hospital-Cornell Medical Center, New York (Drs. Levy and Plum and Mr. Silverman), and the MRC Neuropsychiatry Unit, Medical Research Council Laboratories, Carshalton, Surrey, England (Dr. Brierley).
Footnotes
Accepted for publication Nov 21, 1974.
Read before the 26th annual meeting of the American Academy of Neurology, San Francisco, April 27, 1974.
Reprint requests to Department of Neurology, New York Hospital-Cornell Medical Center, 525 E 68th St, New York, NY 10021 (Dr. Levy).
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ABSTRACT
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