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Report of a Family With Histocompatibility Antigen Typing

Thomas D. Bird, MD

Arch Neurol. 1975;32(6):414-416.

Abstract
Three members of an unusual family were affected with apparent multiple sclerosis in a direct line over three successive generations. Each affected member had clinical remissions and exacerbations and evidence of lesions disseminated in space. One affected member had a cerebrospinal fluid pleocytosis and elevated -globulin level. The genetically determined histocompatibility antigen (HL-A) types are reported for 13 family members. The three affected members had HL-A types 11 and W16 in common.

Author Affiliations
From the Department of Medicine (Neurology), University of Washington School of Medicine, Seattle.

Footnotes
Accepted for publication Aug 26, 1974.

Reprint requests to Department of Medicine (Neurology), University of Washington School of Medicine, Seattle, WA 98195 (Dr. Bird).

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