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A Reappraisal

Cornelio Fazio, MD; Mario Manfredi, MD; Ascanio Piccinelli, MD

Arch Neurol. 1975;32(5):304-307.

Abstract
The therapeutic efficacy of orally administered clonazepam has been evaluated in 32 epileptic patients, with substantial improvement in 22. The drug is active in all types of seizures, particularly in myoclonus, petit mal absences, and partial complex epilepsy; it seems the drug of choice in generalized infantile organic epilepsy, although the treatment of these patients is still unsatisfactory. In some patients, the drug seemed less effective after months of therapy. Drowsiness is the main side effect.

Author Affiliations
From I Clinica delle Malattie Nervose e Mentali dell'Università di Roma, and Ospedale S. Giovanni Battista, Rome.

Footnotes
Accepted for publication July 9, 1974.

Reprint requests to I Clinica delle Malattie Nervose e Mentali dell'Università, Viale dell' Università 30, 00185 Rome, Italy (Dr. Fazio).

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