 |
|
AdrenoleukodystrophyElectron Microscopic Findings
Henry Powell, MB, BCh;
Richard Tindall, MD;
Paul Schultz, MD;
David Paa, MD;
John O'Brien, MD;
Peter Lampert, MD
Arch Neurol. 1975;32(4):250-260.
Abstract
Ultrastructural and neurochemical studies were done on three male patients with adrenoleukodystrophy. In each case, the affected white matter contained enlarged glial cells filled with pathognomic intracytoplasmic inclusions consisting of electron-lucent spicules bounded by 25-Angström wide membranes. Similar inclusions were present in adrenocortical cells. These findings and a review of 47 reported cases indicate that adrenoleu-kodystrophy is a storage disorder caused by a sex-linked recessive error of metabolism.
Author Affiliations
From the Department of Neurosciences, University Hospital and School of Medicine, University of California at San Diego (Drs. Tindall and O'Brien), Childrens Hospital of San Diego (Drs. Schultz and Paa), and Department of Pathology, Veterans Hospital and the University of California at San Diego (Drs. Powell and Lampert).
Footnotes
Accepted for publication Aug 5, 1974.
Reprint requests to Department of Pathology, University of California at San Diego, La Jolla, CA 92037 (Dr. Lampert).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Plant Cuticular Lipid Export Requires an ABC Transporter
Pighin et al.
Science 2004;306:702-704.
ABSTRACT
| FULL TEXT
Peroxisomal Disorders: A Review of a Recently Recognized Group of Clinical Entities
Talwar and Swaiman
CLIN PEDIATR 1987;26:497-504.
ABSTRACT
Use of Adrenal Biopsy in Diagnosing Adrenoleukomyeloneuropathy
Weiss et al.
Arch Neurol 1980;37:634-636.
ABSTRACT
Adrenoleukodystrophy: Report of Two Cases With Relapsing and Remitting Courses
Walsh
Arch Neurol 1980;37:448-450.
ABSTRACT
|
