 |
|
Mechanism of Colistin-Induced Neuromuscular Depression
Michael P. McQuillen, MD;
Lise Engbaek, MD
Arch Neurol. 1975;32(4):235-238.
Abstract
The effect of a high concentration of the antibiotic colistin sulfate on neuromuscular transmission was examined by recording intracellularly from rat diaphragm blocked with tubocurarine chloride. The presynaptic effect of colistin was different from that of neomycin sulfate, which reduces the probability of acetylcholine release: Colistin reduced the quantum content of the initial and the last 20 end-plate potentials of a train of 40 stimuli without altering the probability of acetylcholine release. The quantum size was reduced, while the frequency of miniature end-plate potentials was unchanged.
Author Affiliations
From the Institute of Neurophysiology, University of Copenhagen, Denmark.
Footnotes
Accepted for publication Aug 23, 1974.
Read before the 98th annual meeting of the American Neurological Association, Montreal, June 11, 1973.
Reprint requests to Department of Neurology, Medical College of Wisconsin, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr. McQuillen).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
The Neurotoxicity of Antibacterial Agents
SNAVELY and HODGES
ANN INTERN MED 1984;101:92-104.
ABSTRACT
|
