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Lalit M. Ambani, MD; Melvin H. Van Woert, MD; Sean Murphy, MD

Arch Neurol. 1975;32(2):114-118.

Abstract
Peroxidase and catalase activities were determined in various regions of parkinsonian brains and control brains from patients with nonneurological diseases. The highest peroxidase activity was localized in the substantia nigra of the normal brain. In Parkinson disease, the peroxidase activity was decreased in the substantia nigra, caudate, and putamen. Catalase activity was also reduced in the substantia nigra and putamen of the parkinsonian brain. These enzyme changes may be causally related to the degeneration and depigmentation of the substantia nigra neurons in Parkinson disease.

Author Affiliations
From the departments of internal medicine and pharmacology, Yale University School of Medicine, New Haven, Conn (Drs. Ambani and Van Woert) and the Department of Neurology, St. Vincent Hospital of Worcester, Mass (Dr. Murphy). Dr. Van Woert is now with the Department of Pharmacology, Mount Sinai School of Medicine, New York.

Footnotes
Accepted for publication June 24, 1974.

Read in part before the American Neurological Association, Montreal, June 1973.

Reprint requests to Department of Pharmacology, Mount Sinai School of Medicine, Fifth Ave and 100th St, New York, NY 10029 (Dr. Van Woert).

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