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Starvation and SeizuresObservations on the Electroconvulsive Threshold and Cerebral Metabolism of the Starved Adult Rat
Darryl C. DeVivo, MD;
Kenneth L. Malas;
Mary P. Leckie
Arch Neurol. 1975;32(11):755-760.
Abstract
• Acute starvation of adult rats resulted in a rise In the electroconvulsive threshold at 48 hours (P <.10) and at 72 hours (P <.01), but not at 24 hours. Biochemlcal correlates Included (1) ketonemia and mild hypoglycemia in the blood; (2) a significant rise in the brain cytoplasmic phosphorylation potential and in the energy charge potential; (3) a shift in the brain cytoplasmic oxidation-reduction potential to a more oxidized state; (4) probable partial inhibitions in brain phosphofructokinase and pyruvate dehydrogenase; and (5) relatively small increases in brain sodium (4.1%), potassium (2.4%), and chloride (4.3%). No major differences were seen in brain water content or adenosine triphosphatase activity. The observed cerebral biochemical alterations are believed to be the consequence of increased ketone body utilization, although the precise relationship to the alteration in the electroconvulsive threshold remains unclear.
Author Affiliations
From the departments of pediatrics and neurology, Washington University School of Medicine, and the Division of Neurology, St. Louis Children's Hospital, St. Louis.
Footnotes
Accepted for publication Dec 27,1974.
A preliminary report of these investigations was read before the 44th annual meeting of the Society for Pediatric Research, Washington, DC, May 1, 1974.
Reprint requests to St. Louis Children's Hospital, 500 S Kingshighway, St. Louis, MO 63110 (Dr DeVivo).
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