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Thummala C. Raghuram, MD; Kamala Krishnaswamy, MD

Arch Neurol. 1975;32(10):708-710.

Abstract
• Altered mental status is common in pellagrins. We evaluated the mental status of pellagrins in relation to the neurohormone, serotonin or 5-hydroxytryptamine (5-HT). Levels of 5-hydroxyindoleacetic acid (5-HIAA), an end product of serotonin in the urine and cerebrospinal fluid (CSF), and of platelet 5-HT were determined in a group of pellagrins and in normal subjects. The results indicated that the 5-HT concentration was reduced in platelets and 5-HIAA excretion in urine was below normal levels. The 5-HIAA concentration in CSF was also reduced, suggesting a decrease in 5-HT functional activity in the brain.

Author Affiliations
From the National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.

Footnotes
Accepted for publication Dec 11, 1974.

Reprint requests to National Institute of Nutrition, Tarnaka, Hyderabad-500007, India (Dr. Raghuram).

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