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James O. McNamara, MD; John R. Curran, MD; Hideo H. Itabashi, MD

Arch Neurol. 1975;32(10):699-701.

Abstract
• Two siblings had what we believe to be a unique disorder manifested by stationary congenital ichthyosiform erythroderma coupled with a slowly progressive spastic weakness of adult onset. The disorder was presumably inherited as an autosomal recessive trait. The mechanism by which a genetic mutation would mediate this multiple organ system disorder is unknown.

Author Affiliations
From the departments of neurology and pathology, University of Michigan Medical Center, Ann Arbor.

Footnotes
Accepted for publication Jan 3, 1975.

Dr McNamara is now at Duke University Medical Center, Durham, NC; Dr Curran is in Nampa, Idaho; and Dr Itabashi is at UCLA School of Medicine, Torrance, Calif.

Reprint requests to Box M2900, Division of Neurology, Duke University Medical Center, Durham, NC 27710 (Dr McNamara).

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