 |
|
Glucocorticoids and Mammalian Motor Nerve Excitability
Walter F. Riker, Jr, MD;
Thomas Baker, MS;
Michiko Okamoto, PhD
Arch Neurol. 1975;32(10):688-694.
Abstract
• Short-term treatment of cats with high doses of triamcinolone and related steroids strikingly increased the capacity of soleus motoneurons to generate post-tetanic stimulus-bound repetition (SBR) and the obligatory posttetanic potentiation (PTP) of muscle. The edrophonium chloride (Tensilon)-induced SBR and twitch potentiation were likewise augmented. These effects reflect an increase in the excitability of the motoneuron. This glucocorticoid effect suggests that the motoneuron is the site of the antimyasthenic action of the hormone. Certainly, the enhanced SBR is a neuronal representation of the adverse epileptogenic action of the glucocorticoids. The glucocorticoid effect on motoneuron outlasts the dosing period, suggesting an underlying alteration in the neuron. Other glucocorticoids caused the same effects, but varied in their potencies. Mineralocorticoids were less effective. The single androgen that was tested proved to be minimally effective.
Author Affiliations
From the Department of Pharmacology, Cornell University Medical College, New York.
Footnotes
Accepted for publication Nov 11, 1974.
Reprint requests to Department of Pharmacology, Cornell University Medical College, 1300 York Ave, New York, NY 10021 (Dr. Riker).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
High-Dose Intravenous Methylprednisolone in Myasthenia Gravis
Arsura et al.
Arch Neurol 1985;42:1149-1153.
ABSTRACT
Effects of a Single Methylprednisolone Dose on a Facilitatory Response of Mammalian Motor Nerve
Baker et al.
Arch Neurol 1977;34:349-355.
ABSTRACT
Antimyasthenic Action of Corticosteroids
Hofmann
Arch Neurol 1977;34:356-360.
ABSTRACT
|
