This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (21)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Treatment With Fludrocortisone

Margaret M. Hoehn, MD, FRCP(C)

Arch Neurol. 1975;32(1):50-51.

Abstract
Six parkinsonian patients with symptomatic postural hypotension secondary to levodopa therapy were treated with 0.05 to 0.2 mg of fludrocortisone acetate daily for six to ten months. Severe orthostatic light-headedness and frequent syncope had previously been alleviated only by reducing the dosage of levodopa to levels producing less than optimal antiparkinsonian benefits. In all six patients, symptoms were alleviated satisfactorily, and supine and upright blood pressures returned to normal levels during treatment with fludrocortisone acetate. There were no adverse reactions. Fludrocortisone acetate is an effective and safe drug for the treatment of severe and otherwise intractable postural hypotension secondary to therapy with levodopa.

Author Affiliations
From the Department of Neurology, University of Colorado Medical Center, Denver.

Footnotes
Accepted for publication July 16, 1974.

Reprint requests to Box 116, University of Colorado Medical Center, 4200 E Ninth Ave, Denver, CO 80220 (Dr. Hoehn).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Neurocirculatory Abnormalities in Parkinson Disease With Orthostatic Hypotension: Independence From Levodopa Treatment
Goldstein et al.
Hypertension 2005;46:1333-1339.
ABSTRACT | FULL TEXT  

Association Between Supine Hypertension and Orthostatic Hypotension in Autonomic Failure
Goldstein et al.
Hypertension 2003;42:136-142.
ABSTRACT | FULL TEXT  

Orthostatic hypotension from sympathetic denervation in Parkinson's disease
Goldstein et al.
Neurology 2002;58:1247-1255.
ABSTRACT | FULL TEXT  

Cardiac Sympathetic Denervation in Parkinson Disease
Goldstein et al.
ANN INTERN MED 2000;133:338-347.
ABSTRACT | FULL TEXT