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Ira B. Black, MD; Susan C. Geen

Arch Neurol. 1975;32(1):47-49.

Abstract
Postmortem changes in the activities of tyrosine hydroxylase, dopa decarboxylase, and dopamine-β-hydroxylase were examined in various areas of rat brain. Tyrosine hydroxylase activity decreased in an exponential fashion with a half-time of two to four hours in caudate-putamen, substantia nigra, and locus ceruleus. Dopa decarboxylase activity remained within 20% of control values at five hours in these areas, but then decreased precipitously. Dopamine-β-hydroxylase activity remained within 20% of control for at least 20 hours after death.

Author Affiliations
From the Department of Neurology, Cornell University Medical College, New York.

Footnotes
Accepted for publication Aug 1, 1974.

Reprint requests to Department of Neurology, Cornell University Medical College, 1300 York Ave, New York, NY 10021 (Dr. Black).

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