This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Blocking of Levodopa Effects

Jorge S. Mendez, MD; George C. Cotzias, MD; Ismael Mena, MD; Paul S. Papavasiliou, MD

Arch Neurol. 1975;32(1):44-46.

Abstract
Diphenylhydantoin (DPH) diminished the therapeutic effects of levodopa both in patients with parkinsonism and in patients with chronic manganese poisoning, as well as the levodopa-dependent dyskinesia for which the former were selected. In patients with Huntington chorea, it enhanced chorea and mental agitation and, thus, failed to conform with the postulated pharmacological reciprocity between Parkinson disease and Huntington chorea. These findings are in agreement with experiments done in animals in which DPH blocked a neuronal response to dopamine.

Author Affiliations
From the Medical Research Center, Brookhaven National Laboratory, Upton, NY.

Footnotes
Accepted for publication June 10, 1974.

Reprint requests to Medical Research Center, Brookhaven National Laboratory, Upton, NY 11973 (Dr. Cotzias).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Phenytoin and Cerebellar Lesions: Similar Effects on Cerebral Catecholamine Metabolism
Snider and Snider
Arch Neurol 1977;34:162-167.
ABSTRACT