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Bernard M. Patten, MD; Katharine L. Oliver; W. King Engel, MD

Arch Neurol. 1974;31(5):347-349.

Abstract
Infusions of serotonin into a rat nervemuscle preparation decreased the force of the evoked twitch of anterior tibial and soleus muscles. Antiserotonin drugs (cyproheptadine hydrochloride, methysergide, chlorpromazine hydrochloride) prevented the adverse effect of serotonin if they were given prior to the serotonin infusion. These experiments support the hypothesis that serotonin may play a role in some diseases of muscle.

Author Affiliations
From the Medical Neurology Branch, National Institutes of Health, Bethesda, Md. Dr. Patten is now with the Neuromuscular Disease Division, Department of Neurology, Baylor College of Medicine, Houston.

Footnotes
Accepted for publication May 10, 1974.

Reprint requests to Department of Neurology, Baylor College of Medicine, 1200 Moursund Ave, Houston, TX 77025 (Dr. Patten).

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