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Intramuscular Administration of DiphenylhydantoinHistologic Follow-Up Studies
Ernest E. Serrano, MD;
Buna J. Wilder, MD
Arch Neurol. 1974;31(4):276-278.
Abstract
Thirteen cats were given intramuscular injections of diphenylhydantoin. Eight cats were killed 24 hours following injection, and five at intervals up to four weeks. Hemorrhage and necrosis of muscle tissue were found in five of eight specimens taken at 24 hours, and microscopic crystallization of diphenylhydantoin was seen only in association with necrotic muscle. Crystal morphology was dependent on intracellular or extracellular localization. Chromatographic analysis showed retention of diphenylhydantoin in injection sites at 24 hours.
Author Affiliations
From the Division of Neurology, University of Florida College of Medicine (Drs. Serrano and Wilder), and the Neurology Section, Veterans Administration Hospital (Dr. Wilder), Gainesville, Fla.
Footnotes
Accepted for publication April 8, 1974.
Reprint requests to 111/B1, Veterans Administration Hospital, Gainesville, FL 32602 (Dr. Wilder).
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