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Studies in Patients With Hyperkalemic Periodic Paralysis

Beth Hoskins, PhD; Thomas H. Maren, MD; Frederic Q. Vroom, MD; Maureen A. Jarrell

Arch Neurol. 1974;31(3):187-191.

Abstract
Rates of potassium influx in red blood cells of three patients with hyperkalemic periodic paralysis were studied during attack-free states and during induced attacks of weakness. Potassium influx rates were normal when the patients were free of attacks but decreased during attacks. Twenty-four-hour administration of acetazolamide decreased resting potassium influx rates and minimized any further decreases due to the attack-inducing procedures. The data suggest that acetazolamide administration alters potassium exchange rates between intracellular and extracellular compartments in such a way as to protect from sudden upward surges in plasma potassium levels.

Author Affiliations
From the departments of pharmacology and therapeutics (Drs. Hoskins, Maren, and Ms. Jarrell) and medicine (neurology) (Dr. Vroom), University of Florida College of Medicine, Gainesville.

Footnotes
Accepted for publication Feb 11, 1974.

Reprint requests to Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216 (Dr. Hoskins).

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