This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (75)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Henry B. Dinsdale, MD; David M. Robertson, MD; Richard A. Haas, PhD

Arch Neurol. 1974;31(2):80-87.

Abstract
Cerebral blood flow (CBF) was measured in rabbits subject to acute hypertension produced by angiotensin infusion. Hypertension led to cerebral hyperperfusion at the time of maximum systolic blood pressure (MSBP) with hypoperfusion five minutes post-MSBP. Focal cortical areas of greatly decreased flow were found at MSBP and up to 60 minutes post-MSBP. These regions were located primarily in arterial boundary zones, were confined to cortex, and were usually larger than the territory supplied by a single penetrating cortical arteriole. Angiotensin infused into carotid arteries had no direct effect on CBF. Passive vasodilation and intense vasoconstriction may coexist and breakdown of the blood-brain barrier may result from vascoconstriction rather than passive vasodilation. Locations of ischemic lesions in arterial boundary zones remain unexplained but may reflect an unusual degree of reactivity of vessels in those regions.

Author Affiliations
Kingston, Ontario, Canada

From the Division of Neurology, departments of medicine (Dr. Dinsdale) and pathology (Neuropathology) (Drs. Robertson and Haas), Queen's University, Kingston, Ontario, Canada.

Footnotes
Accepted for publication Nov 14, 1974.

Read in part before the 98th annual meeting of the American Neurological Association and the Canadian Congress of Neurological Sciences, Montreal, June 12, 1973.

Reprint requests to Division of Neurology, 82 Barrie St, Kingston, K7L 3J8, Canada (Dr. Dinsdale)

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Reversible Posterior Leukoencephalopathy Syndrome
Hinchey et al.
NEJM 1996;334:494-500.
ABSTRACT | FULL TEXT  

Cooperative Study of Hospital Frequency and Character of Transient Ischemic Attacks: VI. Patients Examined During an Attack
Price et al.
JAMA 1977;238:2512-2515.
ABSTRACT  

Effect of Cardiac Dysrhythmia on Cerebral Perfusion
Sand et al.
Arch Surg 1976;111:787-791.
ABSTRACT