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An Experimental Model for the Study of Hepatic Encephalopathy
Michael D. Norenberg, MD;
Lowell W. Lapham, MD;
Frank A. Nichols, MD;
Allyn G. May, MD
Arch Neurol. 1974;31(2):106-109.
Abstract
A subacute experimental model of hepatic encephalopathy was created in the rat by constructing a portacaval shunt with subsequent gavage feeding of a cationic ammonium exchange resin. The clinical course was characterized by fluctuating levels of consciousness, bizarre behavior, and motor symptoms leading to coma and death. Histopathologically, proliferation of Alzeimer type II astrocytes in the cerebral cortex was demonstrated. Serum ammonia levels were greatly elevated. This model should be useful in providing a better understanding of the pathogenesis of hepatic coma, and particularly the role of the astrocyte in this process.
Author Affiliations
Denver; Rochester, NY
From the departments of pathology (Drs. Norenberg and Lapham) and surgery (Drs. Nichols and May), University of Rochester (NY) Medical Center, and Veterans Administration Hospital and Department of Pathology, University of Colorado Medical Center (Dr. Norenberg), Denver.
Footnotes
Accepted for publication Dec 31, 1973.
Read in part before the 49th annual meeting of the American Association of Neuropathologists, Freeport, Grand Bahama, June 16, 1973.
Reprint requests to Department of Pathology, Veterans Administration Hospital, 1055 Clermont St, Denver, CO 80220 (Dr. Norenberg).
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