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Similar Ultrastructural Changes in Adrenal Cortical and Schwann Cells

James M. Powers, MD; Herbert H. Schaumburg, MD

Arch Neurol. 1974;30(5):406-408.

Abstract
Ultrastructural observations of an adrenal biopsy specimen from an 11-year-old boy with adreno-leukodystrophy showed that adrenocortical cells contained cytoplasmic accumulations of lamellar material. Each lamella consisted of two parallel, electron-dense 25 Angstrom leaflets separated by a variable 20 A to 70 A space. Rows of glycogen and a clear space often surrounded this material. Similar accumulations were also present in the Schwann cell cytoplasm of many of the myelinated nerve fibers in the adrenal capsule. These findings represent a possible morphologic link between the endocrine and nervous systems in this disease.

Author Affiliations
Bronx, NY

From the Department of Pathology (Neuropathology) (Dr. Powers) and the Saul R. Korey Department of Neurology (Dr. Schaumburg), Albert Einstein College of Medicine, Bronx, NY.

Footnotes
Accepted for publication Oct 23, 1973.

Reprint requests to Department of Pathology, Medical University of South Carolina, 80 Barre St, Charleston, SC 29401 (Dr. Powers).

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