This Article  • References  • Full text PDF  • Correction  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (50)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Antonio V. Lorenzo, PhD; Michael J. Bresnan, MD; Charles F. Barlow, MD

Arch Neurol. 1974;30(5):387-393.

Abstract
Five adults with signs of normal pressure hydrocephalus underwent ventriculolumbar perfusions. Average cerebrospinal fluid (CSF) formation rate, 0.313 ± 0.020 ml/min, was comparable with that for nonhydrocephalics, but due to the larger CSF compartment, turnover rate was approximately one third. Slow turnover was further aggravated by a CSF absorption deficiency.

Normally, absorption begins at approximately 68 mm CSF pressure and increases linearly at a rate of 7.6µl/ min/mm CSF pressure. In four patients the rate was reduced to 2.5µl/min/mm CSF once a critical mean CSF pressure was reached. This absorption deficit, accompanied by elevated pressure plateaus and heightened pulse pressures may lead to ventricular enlargement and, secondarily, to symptoms associated with normal pressure hydrocephalus.

Only two of these four patients showed good response to shunting. In two nonresponding patients, follow-up revealed evidence of complicating intrinsic brain disease.

Author Affiliations
Boston

From the departments of neurology (Drs. Lorenzo, Bresnan, and Barlow) and pharmacology (Dr. Lorenzo), Children's Hospital Medical Center, Harvard Medical School, Boston.

Footnotes
Accepted for publication Sept 25, 1973.

Read before the seventh annual meeting of the Society for Research Into Hydrocephalus and Spina Bifida, Cardiff, Wales, July 7, 1973.

Reprint requests to Children's Hospital Medical Center, 300 Longwood Ave, Boston, MA 02115 (Dr. Lorenzo).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hyperintensities of the Optic Radiation on T2-Weighted MR Images of Elderly Subjects
Kitajima et al.
Am. J. Neuroradiol. 1999;20:1009-1014.
ABSTRACT | FULL TEXT  

Vascular Risk Factors and Arteriosclerotic Disease in Idiopathic Normal-Pressure Hydrocephalus of the Elderly
Krauss et al.
Stroke 1996;27:24-29.
ABSTRACT | FULL TEXT  

Abnormal Cerebrospinal Fluid-Blood Flow Dynamics: Implications in Diagnosis, Treatment, and Prognosis in Normal Pressure Hydrocephalus
Mathew et al.
Arch Neurol 1975;32:657-664.
ABSTRACT