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Multiple Demyelinating Episodes in Rhesus Monkey Sensitized With Rabbit Sciatic Nerve Myelin

Henryk M. Winiewski, MD, PhD; Steven W. Brostoff, PhD; Harry Carter, MD; Edwin H. Eylar, PhD

Arch Neurol. 1974;30(5):347-358.

Abstract
Seven rhesus monkeys immunized with 60 to 70 mg of rabbit sciatic nerve myelin developed neurological symptoms (ptosis, strabismus, paresis, or paralysis). In two animals clinical episodes of the disease recurred. Morphologic studies of the animals between 21 and 70 days after immunization showed that all monkeys developed demyelinating polyganglioradiculoneuritis. Cranial nerves myelinated by Schwann cells were also involved; however, the central nervous system did not display any demyelinating lesions. In all animals, irrespective of postimmunization time lapse and occurrence of clinical symptoms, chronic demyelinating plaques and acute lesions with cellular infiltration, active stripping, and phagocytosis of myelin were observed. Coexistence of active and chronic demyelinating plaques is especially important, particularly in animals that survived long after appearance of clinical symptoms; it indicates that experimental allergic neuritis is not a monophasic disease.

Author Affiliations
Bronx, NY; Rahway, NJ

From the Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY (Drs. Winiewski and Brostoff), and the Merck Institute for Therapeutic Research, Rahway, NJ (Drs. Carter and Eylar).

Footnotes
Accepted for publication Oct 12, 1973.

Reprint requests to Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 (Dr. Winiewski).

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