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Inosiplex and Amyotrophic Lateral SclerosisTherapeutic Trial in Patients on Guam
Jacob A. Brody, MD;
Kwang-Ming Chen, MD;
Yoshiro Yase, MD;
E. Michael Holden, MD;
Charles E. Morris, MD
Arch Neurol. 1974;30(4):322-323.
Abstract
We report negative results in a doubleblind study of the therapeutic value of inosiplex in Guamanian patients with amyotrophic lateral sclerosis. Similar rates of progression and mortality over a two-year period were observed in eight inosiplex-treated patients and eight matched controls who received a placebo, and an additional five patients who received inosiplex but for whom no controls were available. Most patients, whether given placebo or drug, experienced subjective improvement, and some gained weight during the early phase of the study. Regardless of treatment, approximately 25% of the patients did not progress clinically during the two years of observation.
Author Affiliations
Bethesda, Md; Agana, Guam; Wakayama, Japan; Tamuning, Guam; Chapel Hill, NC
From the Epidemiology Branch, C&FR, National Institute of Neurological Diseases and Stroke, Bethesda, Md (Dr. Brody); Guam Memorial Hospital, Agana, Guam (Dr. Chen); Division of Neurological Diseases, Wakayama Medical College, Wakayama, Japan (Dr. Yase); NINDS
Footnotes
Accepted for publication Sept 21, 1973.
Research Center, Tamuning, Guam (Dr. Holden); and University of North Carolina, Chapel Hill (Dr. Morris).
Reprint requests to Epidemiology Branch, C&FR, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20014 (Dr. Brody).
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