This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (66)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Marcus E. Raichle, MD; John O. Eichling, PhD; Robert L. Grubb, Jr., MD

Arch Neurol. 1974;30(4):319-321.

Abstract
The equilibration of labeled water (H₂ ¹⁵O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.. 50 (ml/100 gm)/min] only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.

Author Affiliations
St. Louis

From the Division of Radiation Sciences (Drs. Raichle and Eichling), Mallinckrodt Institute of Radiology; Department of Neurology (Dr. Raichle) and Division of Neurosurgery (Dr. Grubb), Washington University School of Medicine, St. Louis.

Footnotes
Accepted for publication Dec 12, 1973.

Reprint requests to Division or Radiation Sciences, Box 8131, Washington University School of Medicine, St. Louis 63110 (Dr. Raichle).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Drug Transporters in the Central Nervous System: Brain Barriers and Brain Parenchyma Considerations
Lee et al.
Pharmacol. Rev. 2001;53:569-596.
ABSTRACT | FULL TEXT  

Extraction of Water Labeled With Oxygen 15 During Single-Capillary Transit: Influence of Blood Pressure, Osmolarity, and Blood-Brain Barrier Damage
Go et al.
Arch Neurol 1981;38:581-584.
ABSTRACT