This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ellsworth C. Alvord, Jr., MD; Patricia C. Hsu, MS; Rosemarie Thron

Arch Neurol. 1974;30(4):296-299.

Abstract
Quantitative comparisons have been made of the degree of inhibition of migration of buffy coat leukocytes on exposure to various concentrations of several physicochemically separated fractions of brain. By contrast with leukocytes obtained from normal people, those from several patients with multiple sclerosis (MS) are inhibited on exposure to remarkably small concentrations of ultracentrifugally prepared synaptosomes. Stroke patients become comparably sensitized during the first week after the stroke, and some patients with brain tumors are also hypersensitive. Since it is unlikely that patients with MS can be tested before they acquire the disease, it will be very difficult to establish whether autosensitization can be primarily (etiologically) involved in MS. Whether autosensitization can be secondarily (pathogenetically) involved in MS still remains to be proved.

Author Affiliations
Seattle

From the Laboratory of Neuropathology, Department of Pathology, University of Washington, School of Medicine, Seattle.

Footnotes
Accepted for publication Oct 4, 1973.

Reprint requests to Division of Neuropathology, RJ-05, University of Washington, School of Medicine, Seattle 98195 (Dr. Alvord).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Blood Genomics in Human Stroke
Baird
Stroke 2007;38:694-698.
ABSTRACT | FULL TEXT  

The Forgotten Lymphocyte: Immunity and Stroke
Baird
Circulation 2006;113:2035-2036.
FULL TEXT  

Elevated pro-inflammatory CD4+CD28- lymphocytes and stroke recurrence and death
Nadareishvili et al.
Neurology 2004;63:1446-1451.
ABSTRACT | FULL TEXT  

Adoptive Transfer of Myelin Basic Protein-Tolerized Splenocytes to Naive Animals Reduces Infarct Size: A Role for Lymphocytes in Ischemic Brain Injury?
Becker et al.
Stroke 2003;34:1809-1815.
ABSTRACT | FULL TEXT  

Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia
Becker et al.
Proc. Natl. Acad. Sci. USA 1997;94:10873-10878.
ABSTRACT | FULL TEXT