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Modification by Intracerebral Administration of POLY I/C

Robert L. Kriel, MD; Herta Wulff, PhD

Arch Neurol. 1974;30(3):238-241.

Abstract
Subacute sclerosing panencephalitis virus inoculated intracerebrally into suckling hamsters produced approximately a 70% incidence of morbidity and mortality and an 80% virus recovery rate in untreated control animals. A therapeutic regimen, consisting of poly I/C administered intracerebrally three hours before and 7 and 14 days following virus challenge, significantly reduced the incidence of early death and virus isolation. Delay of therapy for 24 hours after virus administration resulted in loss of therapeutic efficacy under the conditions of this experiment. Poly I/C administered intraperitoneally also was without therapeutic benefit.

Author Affiliations
St. Paul, Minn

From the departments of pediatrics and neurology, University of Minnesota Hospital, and St. Paul-Ramsey Hospital and Medical Center, St. Paul, Minn. Dr. Wulff is now with the Virology Branch, Bureau of Laboratories, National Center for Disease Control, Atlanta.

Footnotes
Accepted for publication Oct 1, 1973.

Results read in part before the first annual meeting of the Child Neurology Society, Ann Arbor, Mich, Oct 5, 1972.

Reprint requests to Department of Pediatrics and Neurology, St. Paul-Ramsey Hospital and Medical Center, St. Paul, MN 55101 (Dr. Kriel).

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