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The Chemotherapy of Intracerebral vs Subcutaneous Murine GliomasA Comparative Study of the Effect of VM 26
William R. Shapiro, MD
Arch Neurol. 1974;30(3):222-226.
Abstract
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An anticancer drug, epipodophyllotoxin (VM 26), was administered to mice bearing intracerebral and subcutaneous ependymoblastomas in order to compare the two sites of implantation as models for chemotherapy of brain tumors. VM 26 increased survival of intracerebral tumorbearing animals only about 20% despite a marked inhibition of both intracerebral and subcutaneous tumor growth. The drug depressed the uptake and incorporation of tritiated thymidine into the DNA of tumor implanted in either site, excluding the blood-brain barrier as a cause of the poor results in the survival studies. VM 26 delayed subcutaneous tumor growth by 21 days. The results suggest very little difference in drug effect on tumor itself relative to the implantation site, but considerable difference in the effect on the tumor-bearing animals. Comparison with randomized clinical studies suggest that human response to anticancer drugs is predicted better by the intracerebral survival model than by the subcutaneous model.
Author Affiliations
New York
From the Laboratory of Neurological Oncology, Memorial-Sloan Kettering Cancer Center, and Department of Neurology, Cornell University Medical Center, New York.
Footnotes
Accepted for publication Aug 15, 1973.
Read in part before the annual meeting of the American Association for Cancer Research, Boston, May 5, 1972.
Reprint requests to Laboratory of Neurological Oncology, Memorial-Sloan Kettering Cancer Center, 410 E 68th St, New York 10021 (Dr. Shapiro).
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