This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. Physiologic and Metabolic Aspects

Myron D. Ginsberg, MD; Ronald E. Myers, MD, PhD

Arch Neurol. 1974;30(3):202-208.

Abstract
Nineteen rhesus monkeys received single exposures to carbon monoxide (CO) sufficient to produce consistent neuropathologic lesions. Inhalation of 0.2% CO led to stable plateau levels of blood carboxyhemoglobin, which averaged 76%. The mean arterial blood oxygen content of these animals declined to 4.2 ml/100 ml. The arterial oxygen pressure remained normal. The jugular venous oxygen content exceeded that of the central venous blood during and following the intoxication. Arterial hypotension and metabolic acidosis evolved consistently though to a variable extent. The central venous pressure remained unaltered. Severe respiratory depression occurred only rarely, whereas cardiac arrhythmias constituted a major risk to life during the actual exposure. Ventricular fibrillation occurred in four animals and was fatal in two but could be largely prevented by the use of lidocaine prophylactically. Arterial hypotension led to the death of two animals.

Author Affiliations
Bethesda, Md

From the Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public Health Service, Dept of Health, Education, and Welfare, Bethesda, Md. Dr. Ginsberg is now with the Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication Sept 11, 1973.

Read in part before the 97th annual meeting of the American Neurological Association, Chicago, June 14, 1972.

Reprint requests to Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia 19104 (Dr..Ginsberg).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Periventricular Leukomalacia in Adults: Clinicopathological Study of Four Cases
De Reuck and Eecken
Arch Neurol 1978;35:517-521.
ABSTRACT  

Carbon Monoxide Poisoning
Winter and Miller
JAMA 1976;236:1502-1504.
ABSTRACT  

Hypoxic-Ischemic Leukoencephalopathy in Man
Ginsberg et al.
Arch Neurol 1976;33:5-14.
ABSTRACT