This Article  • References  • Full text PDF  • Correction  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Sodium Na 24 and Carbon 14-Labeled Inulin Kinetics in Diphtheria Toxin-Injected Nerve and the Effect of Hydrocortisone

Victor A. Levin, MD; Ewa Chelmicka-Szorc, MD; Barry G. W. Arnason, MD

Arch Neurol. 1974;30(2):163-168.

Abstract
The compartmental equilibration of sodium Na 24 and carbon 14-labeled inulin was determined in hydrocortisone-treated (24 hours) and untreated rats in which segmental demyelination had been produced in one sciatic nerve by intraneural injection of diphtheria toxin. Diphtheria toxin caused increase in nerve water and sodium content, breakdown of the physiologic blood-nerve extracellular space (ECS) barrier to ²⁴Na and inulin-¹⁴C, slowing of ECS-intracellular space (ICS) exchange of isotopic sodium, enlargement of the nerve ECS, and intracellular swelling. Hydrocortisone was found to restore the blood-nerve ECS barrier to isotopic sodium, reduce the water content of ECS and ICS, and slow blood-ECS exchange of inulin-¹⁴C (although it eventually distributed in nerve ECS at a level equal to that of untreated diphtheria toxin-injected nerve).

Author Affiliations
Boston

From the Department of Neurology, Massachusetts General Hospital, Boston. Parts of this study were done while Dr. Levin was a Special Research Fellow at the National Institute of Neurological Diseases and Stroke.

Footnotes
Accepted for publication Aug 16, 1973.

Reprint requests to HSW 783, departments of neurosurgery, neurology, and pharmaceutical chemistry, University of California, San Francisco 94143 (Dr. Levin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?